DanDi Bioscience

https://www.hankyung.com/it/article/202112096853i 

This post has been translated from the original article dated 12/1/2021. 

Publication of papers in SCI-level international journals

Dandi Bioscience announced on the 9th that it had published a comprehensive thesis proposing a new onset factor and onset mechanism of Alzheimer's disease in 'Translation Neurodegeneration', an international academic journal with the Science and Technology Citation Index (SCI).

The title of the thesis is ‘Gram-negative bacteria and LPS in Alzheimer’s disease: their role in pathogenesis and therapeutic implications’. It was jointly written by Park Young-min, CEO of Dandibio, Moon Min-ho, professor of medicine at Gyeonyang University, and Yang Hyun-deok, director of Harvard Neurology Clinic.

The thesis contains research results to overcome the limitations of Alzheimer's disease treatment. It is about a new treatment approach that can prevent the onset and progression of Alzheimer's disease by controlling gram-negative bacteria and gram-negative bacteria-derived endotoxin (LPS).

The research team confirmed that Gram-negative bacteria and the endotoxin they secrete induce or accelerate Alzheimer's pathology through various mechanisms. In fact, blood analysis of Alzheimer's disease patients also proved that gram-negative free endotoxins are highly correlated with the disease.

The phenomenon of endotoxemia (LPS cascade) was proposed as a potential target for Alzheimer's disease treatment.

Park Young-min, CEO of Dandibio, said, "Although bacterial targeting drugs that control Gram-negative bacteria have shown potential in treating Alzheimer's disease, there are concerns about side effects and safety." This is the best strategy for prevention.”

Dandibio plans to start developing a treatment for Alzheimer's disease. It aims to enter the global phase 1 clinical trial in 2023.

Meanwhile, 'DD-S052', a peptide-based new drug candidate for sepsis, is undergoing preclinical trials. It plans to enter phase 1 in France next year.

Reporter Park In-hyeok